Alcohol: It is unsafe to consume alcohol with Parapal 650mg Tablet SR. Pregnancy: Parapal 650mg Tablet SR may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor. Breastfeeding: Parapal 650mg Tablet SR is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby. Driving: Parapal 650mg Tablet SR does not usually affect your ability to drive. Kidney: Parapal 650mg Tablet SR should be used with caution in patients with kidney disease. Dose adjustment of Parapal 650mg Tablet SR may be needed. Please consult your doctor.However, Parapal 650mg Tablet SR contains paracetamol which is considered the safest painkiller for kidney disease patients. Liver: Parapal 650mg Tablet SR should be used with caution in patients with liver disease. Dose adjustment of Parapal 650mg Tablet SR may be needed. Please consult your doctor.However, the use of Parapal 650mg Tablet SR is not recommended in patients with severe liver disease and active liver disease.