Alcohol: Macfast 125 Oral Suspension should be used with caution in patients with severe kidney disease. Dose adjustment of Macfast 125 Oral Suspension may be needed. Please consult your doctor.However, Macfast 125 Oral Suspension contains paracetamol which is considered the safest painkiller for children with kidney disease. Pregnancy: Macfast 125 Oral Suspension should be used with caution in patients with liver disease. Dose adjustment of Macfast 125 Oral Suspension may be needed. Please consult your doctor.However, the use of Macfast 125 Oral Suspension is not recommended in children with severe liver disease and active liver disease.