Alcohol: It is unsafe to consume alcohol with Hitem 300mg Tablet MD. Pregnancy: Hitem 300mg Tablet MD may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor. Breastfeeding: Hitem 300mg Tablet MD is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby. Driving: Hitem 300mg Tablet MD does not usually affect your ability to drive. Kidney: Hitem 300mg Tablet MD should be used with caution in patients with kidney disease. Dose adjustment of Hitem 300mg Tablet MD may be needed. Please consult your doctor.However, Hitem 300mg Tablet MD contains paracetamol which is considered the safest painkiller for kidney disease patients. Liver: Hitem 300mg Tablet MD should be used with caution in patients with liver disease. Dose adjustment of Hitem 300mg Tablet MD may be needed. Please consult your doctor.However, the use of Hitem 300mg Tablet MD is not recommended in patients with severe liver disease and active liver disease.