Alcohol: Pyrakem 125mg/5ml Suspension should be used with caution in patients with severe kidney disease. Dose adjustment of Pyrakem 125mg/5ml Suspension may be needed. Please consult your doctor.However, Pyrakem 125mg/5ml Suspension contains paracetamol which is considered the safest painkiller for children with kidney disease. Pregnancy: Pyrakem 125mg/5ml Suspension should be used with caution in patients with liver disease. Dose adjustment of Pyrakem 125mg/5ml Suspension may be needed. Please consult your doctor.However, the use of Pyrakem 125mg/5ml Suspension is not recommended in children with severe liver disease and active liver disease.