Alcohol: Pyritec 125mg Oral Suspension should be used with caution in patients with severe kidney disease. Dose adjustment of Pyritec 125mg Oral Suspension may be needed. Please consult your doctor.However, Pyritec 125mg Oral Suspension contains paracetamol which is considered the safest painkiller for children with kidney disease. Pregnancy: Pyritec 125mg Oral Suspension should be used with caution in patients with liver disease. Dose adjustment of Pyritec 125mg Oral Suspension may be needed. Please consult your doctor.However, the use of Pyritec 125mg Oral Suspension is not recommended in children with severe liver disease and active liver disease.