Alcohol: It is unsafe to consume alcohol with Nucyreta 100mg Tablet ER. Pregnancy: Nucyreta 100mg Tablet ER may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor. Breastfeeding: Nucyreta 100mg Tablet ER is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. Driving: Nucyreta 100mg Tablet ER may cause side effects which could affect your ability to drive.If you feel drowsy, dizzy, have blurred vision or a slow reaction time while taking Nucyreta 100mg Tablet ER, then do not drive. Kidney: Nucyreta 100mg Tablet ER should be used with caution in patients with kidney disease. Dose adjustment of Nucyreta 100mg Tablet ER may be needed. Please consult your doctor. Liver: Nucyreta 100mg Tablet ER should be used with caution in patients with severe liver disease. Dose adjustment of Nucyreta 100mg Tablet ER may be needed. Please consult your doctor.Use of Nucyreta 100mg Tablet ER is not recommended in patients with severe kidney disease.