Alcohol: It is unsafe to consume alcohol with Tapodic 50mg Tablet ER. Pregnancy: Tapodic 50mg Tablet ER may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor. Breastfeeding: Tapodic 50mg Tablet ER is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. Driving: Tapodic 50mg Tablet ER may cause side effects which could affect your ability to drive.If you feel drowsy, dizzy, have blurred vision or a slow reaction time while taking Tapodic 50mg Tablet ER, then do not drive. Kidney: Tapodic 50mg Tablet ER should be used with caution in patients with kidney disease. Dose adjustment of Tapodic 50mg Tablet ER may be needed. Please consult your doctor. Liver: Tapodic 50mg Tablet ER should be used with caution in patients with severe liver disease. Dose adjustment of Tapodic 50mg Tablet ER may be needed. Please consult your doctor.Use of Tapodic 50mg Tablet ER is not recommended in patients with severe kidney disease.