Alcohol: Luprex 50mg Syrup is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Luprex 50mg Syrup may not be needed in these patients. Please consult your doctor.Roxithromycin is usually considered safe to use in children with mild to moderate kidney impairment. Dose modifications are generally not required. Pregnancy: Luprex 50mg Syrup should be used with caution in patients with liver disease. Dose adjustment of Luprex 50mg Syrup may be needed. Please consult your doctor.However, discontinue immediately if signs or symptoms of hepatitis like vomiting, paleness, and weakness are observed.