Alcohol: Zofacin 100mg/5ml Syrup should be used with caution in patients with severe kidney disease. Dose adjustment of Zofacin 100mg/5ml Syrup may be needed. Please consult your doctor.Zofacin 100mg/5ml Syrup is usually considered safe to use in children with mild to moderate kidney impairment. Dose modifications are generally not required in children with kidney problems. Pregnancy: Zofacin 100mg/5ml Syrup should be used with caution in patients with liver disease. Dose adjustment of Zofacin 100mg/5ml Syrup may be needed. Please consult your doctor.However, discontinue Zofacin 100mg/5ml Syrup immediately if signs or symptoms of hepatitis like vomiting, paleness, and weakness are observed.