Alcohol: It is unsafe to consume alcohol with Extragesic 37.5mg/375mg Tablet. Pregnancy: Extragesic 37.5mg/375mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor. Breastfeeding: Extragesic 37.5mg/375mg Tablet is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.Consult a doctor immediately if the baby shows signs of increased sleepiness (more than usual), difficulty breastfeeding, breathing problems, or limpness. Driving: Extragesic 37.5mg/375mg Tablet may cause side effects which could affect your ability to drive. Kidney: Extragesic 37.5mg/375mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Extragesic 37.5mg/375mg Tablet may be needed. Please consult your doctor. Liver: Extragesic 37.5mg/375mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Extragesic 37.5mg/375mg Tablet may be needed. Please consult your doctor.However, the use of Extragesic 37.5mg/375mg Tablet is not recommended in patients with severe liver disease and active liver disease.