Alcohol: Twincillin 250mg/250mg Capsule should be used with caution in patients with kidney disease. Dose adjustment of Twincillin 250mg/250mg Capsule may be needed. Please consult your doctor.Regular monitoring of kidney function tests is advised while taking this medicine. Pregnancy: Twincillin 250mg/250mg Capsule should be used with caution in patients with liver disease. Dose adjustment of Twincillin 250mg/250mg Capsule may be needed. Please consult your doctor.Regular monitoring of liver function tests is advised while taking this medicine.