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Topgesic Plus 400mg/325mg/150mg Tablet is a pain relieving medicine. It is used to relieve pain and inflammation in conditions like rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis. It is also used to relieve muscle pain, back pain, toothache, or pain in the ear and throat.Topgesic Plus 400mg/325mg/150mg Tablet should be taken with food. This will prevent you from getting an upset stomach. The dose will depend on what you are taking it for and how well it helps your symptoms. You should take it as advised by your doctor. Do not take more or use it for a longer duration than recommended by the doctor.The most common side effects of this medicine include nausea, indigestion, stomach pain, and diarrhea. If any of these side effects bother you or get worse, you should speak to your doctor. Your doctor may be able to suggest ways of preventing or reducing the side effects.Before taking it, you should let your doctor know if you have a history of ulcer or bleeding in your stomach, high blood pressure, or have any trouble with your heart, kidneys, or liver. Let your doctor also know about all the other medicines you are taking because they may affect, or be affected by, this medicine.Pregnant or breastfeeding women should consult their doctor before starting treatment. You should also avoid drinking alcohol while you are taking this medicine, as alcohol can cause excessive drowsiness.

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Alcohol: It is unsafe to consume alcohol with Topgesic Plus 400mg/325mg/150mg Tablet. Pregnancy: Topgesic Plus 400mg/325mg/150mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor. Breastfeeding: Information regarding the use of Topgesic Plus 400mg/325mg/150mg Tablet during breastfeeding is not available. Please consult your doctor. Driving: Topgesic Plus 400mg/325mg/150mg Tablet does not usually affect your ability to drive. Kidney: Topgesic Plus 400mg/325mg/150mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Topgesic Plus 400mg/325mg/150mg Tablet may be needed. Please consult your doctor.Use of Topgesic Plus 400mg/325mg/150mg Tablet is not recommended in patients with severe kidney disease. Long term use of this medicine can affect the kidney function. Liver: Topgesic Plus 400mg/325mg/150mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Topgesic Plus 400mg/325mg/150mg Tablet may be needed. Please consult your doctor.However, the use of Topgesic Plus 400mg/325mg/150mg Tablet is not recommended in patients with severe liver disease and active liver disease.