Alcohol: It is not known whether it is safe to consume alcohol with Prufex 180 Tablet. Please consult your doctor. Pregnancy: Prufex 180 Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor. Breastfeeding: Prufex 180 Tablet is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.Because of low milk levels and lack of sleepiness, use of Prufex 180 Tablet would not be expected to cause any adverse effects in breastfed babies. Driving: Prufex 180 Tablet does not usually affect your ability to drive.However, you should make check that Prufex 180 Tablet does not make you feel sleepy or dizzy before driving or operating machinery. Kidney: Prufex 180 Tablet should be used with caution in patients with kidney disease. Dose adjustment of Prufex 180 Tablet may be needed. Please consult your doctor. Liver: Prufex 180 Tablet is safe to use in patients with liver disease. No dose adjustment of Prufex 180 Tablet is recommended.However, consult your doctor before giving Prufex 180 Tablet to your child in case of severe liver disease.