Alcohol: It is unsafe to consume alcohol with Orthocal 500mg Tablet. Pregnancy: Orthocal 500mg Tablet is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies. Breastfeeding: Orthocal 500mg Tablet is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby. Driving: Orthocal 500mg Tablet does not usually affect your ability to drive. Kidney: Orthocal 500mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Orthocal 500mg Tablet may be needed. Please consult your doctor. Liver: Orthocal 500mg Tablet is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Orthocal 500mg Tablet may not be needed in these patients. Please consult your doctor.