Alcohol: Consuming alcohol while taking Matrix 400 mg/600 mg Tablet may cause symptoms such as flushing, increased heart beat, nausea, thirst, chest pain and low blood pressure (Disulfiram reaction). Pregnancy: Matrix 400 mg/600 mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor. Breastfeeding: Matrix 400 mg/600 mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. Driving: Matrix 400 mg/600 mg Tablet may cause side effects which could affect your ability to drive.Matrix 400 mg/600 mg Tablet may make you feel drowsy or gives you problems with coordination or sensation (e.g. numbness or weakness). This may affect your driving ability. Kidney: Matrix 400 mg/600 mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Matrix 400 mg/600 mg Tablet may be needed. Please consult your doctor.Use of Matrix 400 mg/600 mg Tablet is not advised in patients with severe kidney disease. Liver: Matrix 400 mg/600 mg Tablet should be used with caution in patients with severe liver disease. Dose adjustment of Matrix 400 mg/600 mg Tablet may be needed. Please consult your doctor.