Alcohol: It is unsafe to consume alcohol with Makdol 50mg Injection. Pregnancy: Makdol 50mg Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor. Breastfeeding: Makdol 50mg Injection is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.Consult a doctor immediately if the baby shows signs of increased sleepiness (more than usual), difficulty breastfeeding, breathing problems, or limpness. Driving: Makdol 50mg Injection may cause side effects which could affect your ability to drive.Makdol 50mg Injection may cause side effects such as drowsiness and blurred vision. If this happens, do not drive. Kidney: Makdol 50mg Injection should be used with caution in patients with kidney disease. Dose adjustment of Makdol 50mg Injection may be needed. Please consult your doctor. Liver: Makdol 50mg Injection should be used with caution in patients with liver disease. Dose adjustment of Makdol 50mg Injection may be needed. Please consult your doctor.