Alcohol: Costigmine 0.5mg/2.5mg Injection may cause excessive drowsiness with alcohol. Pregnancy: Costigmine 0.5mg/2.5mg Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor. Breastfeeding: Costigmine 0.5mg/2.5mg Injection is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.Long-term use of Costigmine 0.5mg/2.5mg Injection might reduce milk production. Driving: Costigmine 0.5mg/2.5mg Injection may cause side effects which could affect your ability to drive.Costigmine 0.5mg/2.5mg Injection may affect vision and coordination. This may affect your driving ability. Kidney: Costigmine 0.5mg/2.5mg Injection should be used with caution in patients with kidney disease. Dose adjustment of Costigmine 0.5mg/2.5mg Injection may be needed. Please consult your doctor.Regular monitoring of kidney function test and some blood tests may advised while you are taking this medicine. Liver: Costigmine 0.5mg/2.5mg Injection is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Costigmine 0.5mg/2.5mg Injection may not be needed in these patients. Please consult your doctor.